<xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:d="http://xbrl.dcca.dk/sob" xmlns:b="http://xbrl.dcca.dk/entryBalanceSheetAccountFormIncomeStatementByNature" xmlns:g="http://xbrl.dcca.dk/mrv" xmlns:f="http://xbrl.dcca.dk/arr" xmlns:e="http://xbrl.dcca.dk/cmn" xmlns:h="http://xbrl.dcca.dk/fsa" xmlns:c="http://xbrl.dcca.dk/gsd" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://xbrl.dcca.dk/entryBalanceSheetAccountFormIncomeStatementByNature http://archprod.service.eogs.dk/taxonomy/20211001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByNatureIncludingManagementsReviewStatisticsAndTax20211001.xsd"><link:schemaRef xlink:type="simple" xlink:href="http://archprod.service.eogs.dk/taxonomy/20211001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByNatureIncludingManagementsReviewStatisticsAndTax20211001.xsd"/><c:ReportingPeriodNumber contextRef="c11" unitRef="u4" decimals="INF">1</c:ReportingPeriodNumber><d:IdentificationOfApprovedAnnualReport contextRef="c11" xml:lang="en">The executive board has today discussed and approved the annual report of Probmet ApS for the financial year 22 February - 31 December 2022.</d:IdentificationOfApprovedAnnualReport><d:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement contextRef="c11" xml:lang="en">The annual report is prepared in accordance with the Danish Financial Statements Act.</d:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement><d:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults contextRef="c11" xml:lang="en">In our opinion, the financial statements give a true and fair view of the company's financial position at 31 December 2022 and of the results of the company's operations for the financial year 22 February - 31 December 2022.</d:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults><d:ManagementsStatementAboutManagementsReview contextRef="c11" xml:lang="en">In our opinion, management's review includes a fair review of the matters dealt with in the management's review.</d:ManagementsStatementAboutManagementsReview><d:ConfirmationThatFinancialStatementsAreExemptedFromAuditing contextRef="c11" xml:lang="en">The financial statements have not been audited. Management considers the criteria for not auditing the financial statements to be met.</d:ConfirmationThatFinancialStatementsAreExemptedFromAuditing><d:RecommendationForApprovalOfAnnualReportByGeneralMeeting contextRef="c11" xml:lang="en">Management recommends that the annual report should be approved by the company in general meeting.</d:RecommendationForApprovalOfAnnualReportByGeneralMeeting><e:NameAndSurnameOfMemberOfExecutiveBoard contextRef="c78">Leonie Sara Young</e:NameAndSurnameOfMemberOfExecutiveBoard><e:NameAndSurnameOfMemberOfExecutiveBoard contextRef="c79">Damir Vareslija</e:NameAndSurnameOfMemberOfExecutiveBoard><f:AddresseeOfAuditorsReportOnOtherReport contextRef="c11" xml:lang="en">To the shareholders of Probmet ApS</f:AddresseeOfAuditorsReportOnOtherReport><f:DescriptionOfOtherEngagement contextRef="c11" xml:lang="en">We have compiled the financial statements of Probmet ApS for the financial year 22 February - 31 December 2022 based on the company's bookkeeping records and other information made available by enterprise.
The financial statements comprises a summary of significant accounting policies, income statement, balance sheet, statement of changes in equity and notes.
We performed the engagement in accordance with ISRS 4410, Compilation Engagements.
We have applied our professional expertise to assist the enterprise in the preparation and presentation of the financial statements in accordance with the Danish Financial Statements Act. We complied with the relevant provisions of the Danish Act on Approved Auditors and with the International Ethics Standards Board for Accountants' Code of Ethics for Professional Accountants (IESBA Code), including principles relating to integrity, objectivity, professional competence and due care.
The financial statements and the accuracy and completeness of the information used to compile the financial statements are the enterprise´s responsibility.
As a compilation engagement is not an assurance engagement, we are not required to verify the accuracy or completeness of the information provided by enterprise for our compilation of the financial statements. Accordingly, we do not express an audit or a review conclusion on whether the financial statements have been prepared in accordance with the Danish Financial Statements Act.</f:DescriptionOfOtherEngagement><f:SignatureOfAuditorsPlace contextRef="c11">Taastrup</f:SignatureOfAuditorsPlace><f:SignatureOfAuditorsDate contextRef="c11">2023-05-30</f:SignatureOfAuditorsDate><e:NameOfAuditFirm contextRef="c12">JH Revision</e:NameOfAuditFirm><e:NameAndSurnameOfAuditor contextRef="c12">Martin Santino Lo Turco</e:NameAndSurnameOfAuditor><e:DescriptionOfAuditor contextRef="c12">statsautoriseret revisor</e:DescriptionOfAuditor><e:IdentificationNumberOfAuditor contextRef="c12">mne35467</e:IdentificationNumberOfAuditor><g:DescriptionOfPrimaryActivitiesOfEntity contextRef="c11" xml:lang="en">Business review
The company's main activity is to develop targeted solutions for patients with breast cancer and brain metastases and related business.</g:DescriptionOfPrimaryActivitiesOfEntity><g:DescriptionOfDevelopmentInActivitiesAndFinancialAffairs contextRef="c11" xml:lang="en">Financial review 
The company's income statement for the year ended 31 December 2022 shows a loss of DKK 440.878, and the balance sheet at 31 December 2022 shows negative equity of DKK 400.878.</g:DescriptionOfDevelopmentInActivitiesAndFinancialAffairs><h:InformationOnReportingClassOfEntity contextRef="c11" xml:lang="en">The annual report of Probmet ApS for 2022 has been prepared in accordance with the provisions of the Danish Financial Statements Act applying to enterprises of reporting class B, as well as provisions applying to reporting class C entities.
As 2022 is the company's first reporting period, no comparatives have been presented.</h:InformationOnReportingClassOfEntity><h:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies contextRef="c11" xml:lang="en">Income is recognised in the income statement as earned, including value adjustments of financial assets and liabilities. All expenses, including amortisation, depreciation and impairment losses, are also recognised in the income statement.
Assets are recognised in the balance sheet when it is probable that future economic benefits will flow to the company and the value of the asset can be measured reliably.
Liabilities are recognised in the balance sheet when it is probable that future economic benefits will flow from the company and the value of the liability can be measured reliably.
On initial recognition, assets and liabilities are measured at cost. On subsequent recognition, assets and liabilities are measured as described below for each individual accounting item.
Certain financial assets and liabilities are measured at amortised cost using the effective interest method. Amortised cost is calculated as the historic cost less any installments and plus/less the accumulated amortisation of the difference between the cost and the nominal amount.
On recognition and measurement, allowance is made for predictable losses and risks which occur before the annual report is presented and which confirm or invalidate matters existing at the balance sheet date.</h:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfRevenue contextRef="c11" xml:lang="en">Revenue is measured at the fair value of the agreed consideration, excluding VAT and other indirect taxes. Revenue is net of all types of discounts granted.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfRevenue><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfExternalExpenses contextRef="c11" xml:lang="en">Other external expenses include expenses related to distribution, sale, advertising, administration, premises, bad debts, payments under operating leases, etc.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfExternalExpenses><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfEmployeeBenefitExpense contextRef="c11" xml:lang="en">Staff costs include wages and salaries, including compensated absence and pensions, as well as other social security contributions, etc. made to the entity's employees.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfEmployeeBenefitExpense><h:DescriptionOfMethodsOfImpairmentLossesAndDepreciation contextRef="c11" xml:lang="en">Amortisation, depreciation and impairment losses comprise the year's amortisation, depreciation and impairment of intangible assets and property, plant and equipment.</h:DescriptionOfMethodsOfImpairmentLossesAndDepreciation><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfFinanceIncomeAndExpenses contextRef="c11" xml:lang="en">Financial income and expenses are recognised in the income statement at the amounts that relate to the financial year. Net financials include interest income and expenses, financial expenses relating to finance leases, realised and unrealised capital/exchange gains and losses on securities, liabilities and foreign currency transactions, amortisation of financial assets and liabilities and surcharges and allowances under the Danish Tax Prepayment Scheme, etc.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfFinanceIncomeAndExpenses><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxExpenses contextRef="c11" xml:lang="en">Tax for the year, which comprises the current tax charge for the year and changes in the deferred tax charge, is recognised in the income statement as regards the portion that relates to the profit/loss for the year and directly in equity as regards the portion that relates to entries directly in equity.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxExpenses><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables contextRef="c11" xml:lang="en">Receivables are measured at amortised cost.
An impairment loss is recognised if there is objective evidence that a receivable or a group of receivables is impaired. If there is objective evidence that an individual receivable is impaired, an impairment loss for that individual asset is recognised.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents contextRef="c11" xml:lang="en">Cash and cash equivalents comprise cash and deposits at banks.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxPayablesAndDeferredTax contextRef="c11" xml:lang="en">Current tax liabilities and current tax receivables are recognised in the balance sheet as the estimated tax on the taxable income for the year, adjusted for tax on the taxable income for previous years and tax paid on account.
Deferred tax is measured according to the liability method in respect of temporary differences between the carrying amount of assets and liabilities and their tax base, calculated on the basis of the planned use of the asset and settlement of the liability, respectively. Deferred tax is measured at net realisable value.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxPayablesAndDeferredTax><h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions contextRef="c11" xml:lang="en">Liabilities, which include trade payables, payables to group entities and other payables, are measured at amortised cost, which is usually equivalent to nominal value.</h:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions><h:Revenue contextRef="c11" unitRef="u3" decimals="0">400000</h:Revenue><h:OtherExternalExpenses contextRef="c11" unitRef="u3" decimals="0">645917</h:OtherExternalExpenses><h:GrossResult contextRef="c11" unitRef="u3" decimals="0">-245917</h:GrossResult><h:EmployeeBenefitsExpense contextRef="c11" unitRef="u3" decimals="0">115354</h:EmployeeBenefitsExpense><h:ProfitLossFromOrdinaryOperatingActivities contextRef="c11" unitRef="u3" decimals="0">-361271</h:ProfitLossFromOrdinaryOperatingActivities><h:OtherFinanceExpenses contextRef="c11" unitRef="u3" decimals="0">79607</h:OtherFinanceExpenses><h:ProfitLossFromOrdinaryActivitiesBeforeTax contextRef="c11" unitRef="u3" decimals="0">-440878</h:ProfitLossFromOrdinaryActivitiesBeforeTax><h:TaxExpense contextRef="c11" unitRef="u3" decimals="0">0</h:TaxExpense><h:ProfitLoss contextRef="c11" unitRef="u3" decimals="0">-440878</h:ProfitLoss><h:ProfitLoss contextRef="c46" unitRef="u3" decimals="0">-440878</h:ProfitLoss><h:OtherShorttermReceivables contextRef="c49" unitRef="u3" decimals="0">145350</h:OtherShorttermReceivables><h:ShorttermReceivables contextRef="c49" unitRef="u3" decimals="0">145350</h:ShorttermReceivables><h:CashAndCashEquivalents contextRef="c49" unitRef="u3" decimals="0">4174731</h:CashAndCashEquivalents><h:CurrentAssets contextRef="c49" unitRef="u3" decimals="0">4320081</h:CurrentAssets><h:Assets contextRef="c49" unitRef="u3" decimals="0">4320081</h:Assets><h:ContributedCapital contextRef="c49" unitRef="u3" decimals="0">40000</h:ContributedCapital><h:RetainedEarnings contextRef="c49" unitRef="u3" decimals="0">-440878</h:RetainedEarnings><h:Equity contextRef="c49" unitRef="u3" decimals="0">-400878</h:Equity><h:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments contextRef="c49" unitRef="u3" decimals="0">4067333</h:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments><h:LongtermLiabilitiesOtherThanProvisions contextRef="c49" unitRef="u3" decimals="0">4067333</h:LongtermLiabilitiesOtherThanProvisions><h:ShorttermTradePayables contextRef="c49" unitRef="u3" decimals="0">517126</h:ShorttermTradePayables><h:OtherShorttermPayables contextRef="c49" unitRef="u3" decimals="0">136500</h:OtherShorttermPayables><h:ShorttermLiabilitiesOtherThanProvisions contextRef="c49" unitRef="u3" decimals="0">653626</h:ShorttermLiabilitiesOtherThanProvisions><h:LiabilitiesOtherThanProvisions contextRef="c49" unitRef="u3" decimals="0">4720959</h:LiabilitiesOtherThanProvisions><h:LiabilitiesAndEquity contextRef="c49" unitRef="u3" decimals="0">4320081</h:LiabilitiesAndEquity><h:Equity contextRef="c87" unitRef="u3" decimals="0">40000</h:Equity><h:Equity contextRef="c105" unitRef="u3" decimals="0">0</h:Equity><h:ProfitLoss contextRef="c106" unitRef="u3" decimals="0">-440878</h:ProfitLoss><h:Equity contextRef="c89" unitRef="u3" decimals="0">40000</h:Equity><h:Equity contextRef="c107" unitRef="u3" decimals="0">-440878</h:Equity><h:WagesAndSalaries contextRef="c11" unitRef="u3" decimals="0">115354</h:WagesAndSalaries><h:EmployeeBenefitsExpense contextRef="c11" unitRef="u3" decimals="0">115354</h:EmployeeBenefitsExpense><h:AverageNumberOfEmployees contextRef="c11" unitRef="u4" decimals="INF">1</h:AverageNumberOfEmployees><h:OtherInterestExpenses contextRef="c11" unitRef="u3" decimals="0">79607</h:OtherInterestExpenses><h:OtherFinanceExpenses contextRef="c11" unitRef="u3" decimals="0">79607</h:OtherFinanceExpenses><c:InformationOnTypeOfSubmittedReport contextRef="c11">Årsrapport</c:InformationOnTypeOfSubmittedReport><c:IdentificationNumberCvrOfSubmittingEnterprise contextRef="c11">55399719</c:IdentificationNumberCvrOfSubmittingEnterprise><c:NameOfSubmittingEnterprise contextRef="c11">JH Revision Godkendt Revisionspartnerselskab</c:NameOfSubmittingEnterprise><c:AddressOfSubmittingEnterpriseStreetAndNumber contextRef="c11">Kingosvej 3</c:AddressOfSubmittingEnterpriseStreetAndNumber><c:AddressOfSubmittingEnterprisePostcodeAndTown contextRef="c11">2630 Taastrup</c:AddressOfSubmittingEnterprisePostcodeAndTown><c:ReportingPeriodStartDate contextRef="c11">2022-02-22</c:ReportingPeriodStartDate><c:ReportingPeriodEndDate contextRef="c11">2022-12-31</c:ReportingPeriodEndDate><c:IdentificationNumberCvrOfReportingEntity contextRef="c11">43125397</c:IdentificationNumberCvrOfReportingEntity><c:NameOfReportingEntity contextRef="c11">Probmet ApS</c:NameOfReportingEntity><c:AddressOfReportingEntityStreetName contextRef="c11">Ole Maaløes Vej</c:AddressOfReportingEntityStreetName><c:AddressOfReportingEntityStreetBuildingIdentifier contextRef="c11">3. 3.</c:AddressOfReportingEntityStreetBuildingIdentifier><c:AddressOfReportingEntityPostCodeIdentifier contextRef="c11">2200</c:AddressOfReportingEntityPostCodeIdentifier><c:AddressOfReportingEntityDistrictName contextRef="c11">København N</c:AddressOfReportingEntityDistrictName><c:AddressOfReportingEntityCountryIdentificationCode contextRef="c11">DK</c:AddressOfReportingEntityCountryIdentificationCode><c:AddressOfReportingEntityCountry contextRef="c11">Danmark</c:AddressOfReportingEntityCountry><c:DateOfFoundationOfReportingEntity contextRef="c11">2022-02-22</c:DateOfFoundationOfReportingEntity><c:RegisteredOfficeOfReportingEntity contextRef="c11">København</c:RegisteredOfficeOfReportingEntity><e:NameOfAuditFirm contextRef="c12">JH Revision</e:NameOfAuditFirm><e:IdentificationNumberCvrOfAuditFirm contextRef="c12">55399719</e:IdentificationNumberCvrOfAuditFirm><e:NameAndSurnameOfAuditor contextRef="c12">Martin Santino Lo Turco</e:NameAndSurnameOfAuditor><e:DescriptionOfAuditor contextRef="c12">statsautoriseret revisor</e:DescriptionOfAuditor><c:AddressOfAuditorStreetName contextRef="c12">Kingosvej</c:AddressOfAuditorStreetName><c:AddressOfAuditorStreetBuildingIdentifier contextRef="c12">3</c:AddressOfAuditorStreetBuildingIdentifier><c:AddressOfAuditorPostCodeIdentifier contextRef="c12">2630</c:AddressOfAuditorPostCodeIdentifier><c:AddressOfAuditorDistrictName contextRef="c12">Taastrup</c:AddressOfAuditorDistrictName><c:AddressOfAuditorCountryIdentificationCode contextRef="c12">DK</c:AddressOfAuditorCountryIdentificationCode><c:TelephoneNumberOfAuditor contextRef="c12">43999292</c:TelephoneNumberOfAuditor><c:EmailOfAuditor contextRef="c11">info@jh-revision.dk</c:EmailOfAuditor><c:DateOfGeneralMeeting contextRef="c11">2023-05-30</c:DateOfGeneralMeeting><c:NameAndSurnameOfChairmanOfGeneralMeeting contextRef="c11">Leonie Sara Young</c:NameAndSurnameOfChairmanOfGeneralMeeting><h:ClassOfReportingEntity contextRef="c11">Regnskabsklasse B</h:ClassOfReportingEntity><h:SelectedElementsFromReportingClassC contextRef="c11">true</h:SelectedElementsFromReportingClassC><e:TypeOfAuditorAssistance contextRef="c11">Andre erklæringer uden sikkerhed</e:TypeOfAuditorAssistance><c:ToolForPreparingTheXBRLInstanceDocument contextRef="c11">CaseWare-FSR</c:ToolForPreparingTheXBRLInstanceDocument><!--Aktuelle periode enkelt selskab--><context id="c11"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><startDate>2022-02-22</startDate><endDate>2022-12-31</endDate></period></context><!--REVISOR1--><context id="c12"><entity><identifier 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scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><startDate>2022-02-22</startDate><endDate>2022-12-31</endDate></period><scenario><xbrldi:typedMember dimension="e:IdentificationOfMemberOfExecutiveBoardDimension"><e:memberOfBoardIdentifier>1</e:memberOfBoardIdentifier></xbrldi:typedMember></scenario></context><!--CEO2--><context id="c79"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><startDate>2022-02-22</startDate><endDate>2022-12-31</endDate></period><scenario><xbrldi:typedMember dimension="e:IdentificationOfMemberOfExecutiveBoardDimension"><e:memberOfBoardIdentifier>2</e:memberOfBoardIdentifier></xbrldi:typedMember></scenario></context><!--Virksomhedskapital aktuel primo--><context id="c87"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><instant>2022-02-22</instant></period><scenario><xbrldi:explicitMember dimension="h:ClassesOfEquityDimension">h:ContributedCapitalMember</xbrldi:explicitMember></scenario></context><!--Virksomhedskapital aktuel ultimo--><context id="c89"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><instant>2022-12-31</instant></period><scenario><xbrldi:explicitMember dimension="h:ClassesOfEquityDimension">h:ContributedCapitalMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel primo--><context id="c105"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><instant>2022-02-22</instant></period><scenario><xbrldi:explicitMember dimension="h:ClassesOfEquityDimension">h:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel i aaret--><context id="c106"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><startDate>2022-02-22</startDate><endDate>2022-12-31</endDate></period><scenario><xbrldi:explicitMember dimension="h:ClassesOfEquityDimension">h:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel ultimo--><context id="c107"><entity><identifier scheme="http://www.dcca.dk/cvr">43125397</identifier></entity><period><instant>2022-12-31</instant></period><scenario><xbrldi:explicitMember dimension="h:ClassesOfEquityDimension">h:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--DKK enere--><unit id="u3"><measure>iso4217:DKK</measure></unit><!--Antal--><unit id="u4"><measure>xbrli:pure</measure></unit></xbrl>
