<xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:c="http://xbrl.dcca.dk/sob" xmlns:b="http://xbrl.dcca.dk/entryBalanceSheetAccountFormIncomeStatementByNature" xmlns:f="http://xbrl.dcca.dk/mrv" xmlns:e="http://xbrl.dcca.dk/arr" xmlns:d="http://xbrl.dcca.dk/cmn" xmlns:h="http://xbrl.dcca.dk/gsd" xmlns:g="http://xbrl.dcca.dk/fsa" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://xbrl.dcca.dk/entryBalanceSheetAccountFormIncomeStatementByNature http://archprod.service.eogs.dk/taxonomy/20201001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByNatureIncludingManagementsReviewStatisticsAndTax20201001.xsd"><link:schemaRef xlink:type="simple" xlink:href="http://archprod.service.eogs.dk/taxonomy/20201001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByNatureIncludingManagementsReviewStatisticsAndTax20201001.xsd"/><c:IdentificationOfApprovedAnnualReport contextRef="c11" xml:lang="en">The executive board has today discussed and approved the annual report of BioClinica ApS for the financial year 31. juli 2020 - 31. december 2021.</c:IdentificationOfApprovedAnnualReport><c:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement contextRef="c11" xml:lang="en">The annual report is prepared in accordance with the Danish Financial Statements Act.</c:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement><c:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults contextRef="c11" xml:lang="en">In my opinion, the financial statements give a true and fair view of the company's financial position at 31. december 2021 and of the results of the company's operations for the financial year 31. juli 2020 - 31. december 2021.</c:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults><c:ManagementsStatementAboutManagementsReview contextRef="c11" xml:lang="en">In my opinion, management's review includes a fair review of the matters dealt with in the management's review.</c:ManagementsStatementAboutManagementsReview><c:RecommendationForApprovalOfAnnualReportByGeneralMeeting contextRef="c11" xml:lang="en">Management recommends that the annual report should be approved by the company in general meeting.</c:RecommendationForApprovalOfAnnualReportByGeneralMeeting><d:NameAndSurnameOfMemberOfExecutiveBoard contextRef="c78">Maureen Waters Marchek</d:NameAndSurnameOfMemberOfExecutiveBoard><d:TitleOfMemberOfExecutiveBoard contextRef="c78">Director</d:TitleOfMemberOfExecutiveBoard><e:AddresseeOfAuditorsReportOnOtherReport contextRef="c11" xml:lang="en">To the shareholder of BioClinica ApS</e:AddresseeOfAuditorsReportOnOtherReport><e:DescriptionOfOtherEngagement contextRef="c11" xml:lang="en">We have compiled the financial statements of BioClinica ApS for the financial year 31. juli 2020 - 31. december 2021 based on the company's bookkeeping records and other information made available by enterprise.
The financial statements comprises a summary of significant accounting policies, income statement, balance sheet, statement of changes in equity and notes.
We performed the engagement in accordance with ISRS 4410, Compilation Engagements.
We have applied our professional expertise to assist the enterprise in the preparation and presentation of the financial statements in accordance with the Danish Financial Statements Act. We complied with the relevant provisions of the Danish Act on Approved Auditors and with the International Ethics Standards Board for Accountants' Code of Ethics for Professional Accountants (IESBA Code), including principles relating to integrity, objectivity, professional competence and due care.
The financial statements and the accuracy and completeness of the information used to compile the financial statements are the enterprise´s responsibility.
As a compilation engagement is not an assurance engagement, we are not required to verify the accuracy or completeness of the information provided by enterprise for our compilation of the financial statements. Accordingly, we do not express an audit or a review conclusion on whether the financial statements have been prepared in accordance with the Danish Financial Statements Act.</e:DescriptionOfOtherEngagement><e:SignatureOfAuditorsPlace contextRef="c11">Copenhagen</e:SignatureOfAuditorsPlace><e:SignatureOfAuditorsDate contextRef="c11">2022-06-24</e:SignatureOfAuditorsDate><d:NameOfAuditFirm contextRef="c12">Ecovis Danmark</d:NameOfAuditFirm><d:NameAndSurnameOfAuditor contextRef="c12">Kurt Bülow</d:NameAndSurnameOfAuditor><d:DescriptionOfAuditor contextRef="c12">Statsautoriseret revisor</d:DescriptionOfAuditor><d:IdentificationNumberOfAuditor contextRef="c12">mne3112</d:IdentificationNumberOfAuditor><f:DescriptionOfPrimaryActivitiesOfEntity contextRef="c11" xml:lang="en">Business review
The company's main activity is to provide products and services to assist pharmaceutical, biotechnology and pharmaceutical companies, as well as other companies involved in life science, in developing new life-enhancing treatments more efficiently and safely, including through facilitating the performance of clinical trials of such in companies in Denmark and in the rest of the world in accordance with applicable ethical and health regulations.</f:DescriptionOfPrimaryActivitiesOfEntity><g:GrossProfitLoss contextRef="c11" unitRef="u3" decimals="0">-86800</g:GrossProfitLoss><g:OtherFinanceExpenses contextRef="c11" unitRef="u3" decimals="0">999</g:OtherFinanceExpenses><g:ProfitLoss contextRef="c11" unitRef="u3" decimals="0">-87799</g:ProfitLoss><g:ProfitLoss contextRef="c46" unitRef="u3" decimals="0">-87799</g:ProfitLoss><g:OtherShorttermReceivables contextRef="c49" unitRef="u3" decimals="0">1550</g:OtherShorttermReceivables><g:ShorttermReceivables contextRef="c49" unitRef="u3" decimals="0">1550</g:ShorttermReceivables><g:CashAndCashEquivalents contextRef="c49" unitRef="u3" decimals="0">80651</g:CashAndCashEquivalents><g:CurrentAssets contextRef="c49" unitRef="u3" decimals="0">82201</g:CurrentAssets><g:Assets contextRef="c49" unitRef="u3" decimals="0">82201</g:Assets><g:ContributedCapital contextRef="c49" unitRef="u3" decimals="0">40000</g:ContributedCapital><g:RetainedEarnings contextRef="c49" unitRef="u3" decimals="0">-87799</g:RetainedEarnings><g:Equity contextRef="c49" unitRef="u3" decimals="0">-47799</g:Equity><g:ShorttermPayablesToGroupEnterprises contextRef="c49" unitRef="u3" decimals="0">100000</g:ShorttermPayablesToGroupEnterprises><g:OtherShorttermPayables contextRef="c49" unitRef="u3" decimals="0">30000</g:OtherShorttermPayables><g:ShorttermLiabilitiesOtherThanProvisions contextRef="c49" unitRef="u3" decimals="0">130000</g:ShorttermLiabilitiesOtherThanProvisions><g:LiabilitiesOtherThanProvisions contextRef="c49" unitRef="u3" decimals="0">130000</g:LiabilitiesOtherThanProvisions><g:LiabilitiesAndEquity contextRef="c49" unitRef="u3" decimals="0">82201</g:LiabilitiesAndEquity><g:Equity contextRef="c87" unitRef="u3" decimals="0">40000</g:Equity><g:Equity contextRef="c105" unitRef="u3" decimals="0">0</g:Equity><g:ProfitLoss contextRef="c106" unitRef="u3" decimals="0">-87799</g:ProfitLoss><g:Equity contextRef="c89" unitRef="u3" decimals="0">40000</g:Equity><g:Equity contextRef="c107" unitRef="u3" decimals="0">-87799</g:Equity><g:DisclosureOfUncertaintiesRelatingToGoingConcern contextRef="c11" xml:lang="en">Support declaration

Sole shareholder Bioclinica, INC., declare it will support Bioclinica ApS 2021 (CVR-nr. 41 59 09 39) economic and financial, to ensure the activities in the subsidiary in the next 12 months from General Assembly for the financial year 2021.

The purpose of the support declaration is to ensure all payment obligations to financial creditors and creditors in general.</g:DisclosureOfUncertaintiesRelatingToGoingConcern><g:InformationOnRelatedEntities contextRef="c11" xml:lang="en">According to the company’s register of shareholders, the following shareholder holds at least 5% of the votes or at least 5% of the share capital:</g:InformationOnRelatedEntities><h:InformationOnTypeOfSubmittedReport contextRef="c11">Årsrapport</h:InformationOnTypeOfSubmittedReport><h:IdentificationNumberCvrOfSubmittingEnterprise contextRef="c11">28939523</h:IdentificationNumberCvrOfSubmittingEnterprise><h:NameOfSubmittingEnterprise contextRef="c11">Ecovis Danmark</h:NameOfSubmittingEnterprise><h:AddressOfSubmittingEnterpriseStreetAndNumber contextRef="c11">Vendersgade 28 st. th</h:AddressOfSubmittingEnterpriseStreetAndNumber><h:AddressOfSubmittingEnterprisePostcodeAndTown contextRef="c11">1363 København K</h:AddressOfSubmittingEnterprisePostcodeAndTown><h:ReportingPeriodStartDate contextRef="c11">2020-07-31</h:ReportingPeriodStartDate><h:ReportingPeriodEndDate contextRef="c11">2021-12-31</h:ReportingPeriodEndDate><h:IdentificationNumberCvrOfReportingEntity contextRef="c11">41590939</h:IdentificationNumberCvrOfReportingEntity><h:NameOfReportingEntity contextRef="c11">BioClinica ApS</h:NameOfReportingEntity><h:AddressOfReportingEntityStreetName contextRef="c11">Axeltorv</h:AddressOfReportingEntityStreetName><h:AddressOfReportingEntityStreetBuildingIdentifier contextRef="c11">2</h:AddressOfReportingEntityStreetBuildingIdentifier><h:AddressOfReportingEntityPostCodeIdentifier contextRef="c11">1609</h:AddressOfReportingEntityPostCodeIdentifier><h:AddressOfReportingEntityDistrictName contextRef="c11">København V</h:AddressOfReportingEntityDistrictName><h:AddressOfReportingEntityCountryIdentificationCode contextRef="c11">DK</h:AddressOfReportingEntityCountryIdentificationCode><h:AddressOfReportingEntityCountry contextRef="c11">Danmark</h:AddressOfReportingEntityCountry><h:DateOfFoundationOfReportingEntity contextRef="c11">2020-07-31</h:DateOfFoundationOfReportingEntity><h:RegisteredOfficeOfReportingEntity contextRef="c11">København</h:RegisteredOfficeOfReportingEntity><d:NameOfAuditFirm contextRef="c12">Ecovis Danmark</d:NameOfAuditFirm><d:IdentificationNumberCvrOfAuditFirm contextRef="c12">28939523</d:IdentificationNumberCvrOfAuditFirm><d:NameAndSurnameOfAuditor contextRef="c12">Kurt Bülow</d:NameAndSurnameOfAuditor><d:DescriptionOfAuditor contextRef="c12">Statsautoriseret revisor</d:DescriptionOfAuditor><h:AddressOfAuditorStreetName contextRef="c12">Vendersgade</h:AddressOfAuditorStreetName><h:AddressOfAuditorStreetBuildingIdentifier contextRef="c12">28 st. th</h:AddressOfAuditorStreetBuildingIdentifier><h:AddressOfAuditorPostCodeIdentifier contextRef="c12">1363</h:AddressOfAuditorPostCodeIdentifier><h:AddressOfAuditorDistrictName contextRef="c12">København K</h:AddressOfAuditorDistrictName><h:AddressOfAuditorCountryIdentificationCode contextRef="c12">DK</h:AddressOfAuditorCountryIdentificationCode><h:AddressOfAuditorCountry contextRef="c12">Danmark</h:AddressOfAuditorCountry><h:TelephoneNumberOfAuditor contextRef="c12">57 61 45 40</h:TelephoneNumberOfAuditor><h:DateOfGeneralMeeting contextRef="c11">2022-06-24</h:DateOfGeneralMeeting><h:NameAndSurnameOfChairmanOfGeneralMeeting contextRef="c11">Maureen Waters Marchek</h:NameAndSurnameOfChairmanOfGeneralMeeting><g:ClassOfReportingEntity contextRef="c11">Regnskabsklasse B</g:ClassOfReportingEntity><g:SelectedElementsFromReportingClassC contextRef="c11">true</g:SelectedElementsFromReportingClassC><d:TypeOfAuditorAssistance contextRef="c11">Andre erklæringer uden sikkerhed</d:TypeOfAuditorAssistance><h:ToolForPreparingTheXBRLInstanceDocument contextRef="c11">CaseWare-FSR</h:ToolForPreparingTheXBRLInstanceDocument><g:InformationOnReportingClassOfEntity contextRef="c11" xml:lang="en">The annual report of BioClinica ApS for 2020/21 has been prepared in accordance with the provisions of the Danish Financial Statements Act applying to reporting class B entities, as well as provisions applying to reporting class C entities.
The annual report for 2020/21 is presented in DKK
As 2020/21 is the company's first reporting period, no comparatives have been presented.</g:InformationOnReportingClassOfEntity><g:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies contextRef="c11" xml:lang="en">Income is recognised in the income statement as earned, including value adjustments of financial assets and liabilities. All expenses, including amortisation, depreciation and impairment losses, are also recognised in the income statement.
Assets are recognised in the balance sheet when it is probable that future economic benefits will flow to the company and the value of the asset can be measured reliably.
Liabilities are recognised in the balance sheet when it is probable that future economic benefits will flow from the company and the value of the liability can be measured reliably.
On initial recognition, assets and liabilities are measured at cost. On subsequent recognition, assets and liabilities are measured as described below for each individual accounting item.
Certain financial assets and liabilities are measured at amortised cost using the effective interest method. Amortised cost is calculated as the historic cost less any installments and plus/less the accumulated amortisation of the difference between the cost and the nominal amount.
On recognition and measurement, allowance is made for predictable losses and risks which occur before the annual report is presented and which confirm or invalidate matters existing at the balance sheet date.</g:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies><g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfGrossProfitLoss contextRef="c11" xml:lang="en">In pursuance of section 32 of the Danish Financial Statements Act, the company does not disclose its revenue. 
Gross profit reflects an aggregation of revenue, changes in inventories of finished goods and work in progress and other operating income less costs of raw materials and consumables and other external expenses.</g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfGrossProfitLoss><g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfExternalExpenses contextRef="c11" xml:lang="en">Other external expenses include expenses related to distribution and administration etc.</g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfExternalExpenses><g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables contextRef="c11" xml:lang="en">Receivables are measured at amortised cost.</g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables><g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents contextRef="c11" xml:lang="en">Cash and cash equivalents comprise cash and deposits at banks.</g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents><g:DescriptionOfMethodsOfDividends contextRef="c11" xml:lang="en">Dividends
Proposed dividends are disclosed as a separate item under equity. Dividends are recognised as a liability when declared by the annual general meeting of shareholders.</g:DescriptionOfMethodsOfDividends><g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions contextRef="c11" xml:lang="en">Liabilities, which include payables to group entities and other payables, are measured at amortised cost, which is usually equivalent to nominal value.</g:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions><!--Aktuelle periode enkelt selskab--><context id="c11"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><startDate>2020-07-31</startDate><endDate>2021-12-31</endDate></period></context><!--REVISOR1--><context id="c12"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><startDate>2020-07-31</startDate><endDate>2021-12-31</endDate></period><scenario><xbrldi:typedMember dimension="d:IdentificationOfAuditorDimension"><d:auditorIdentifier>1</d:auditorIdentifier></xbrldi:typedMember></scenario></context><!--Overfoert resultat aktuel i aaret--><context id="c46"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><startDate>2020-07-31</startDate><endDate>2021-12-31</endDate></period><scenario><xbrldi:explicitMember dimension="g:ResultDistributionDimension">g:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--Slutdato aktuelle periode enkelt selskab--><context id="c49"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><instant>2021-12-31</instant></period></context><!--CEO1--><context id="c78"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><startDate>2020-07-31</startDate><endDate>2021-12-31</endDate></period><scenario><xbrldi:typedMember dimension="d:IdentificationOfMemberOfExecutiveBoardDimension"><d:memberOfBoardIdentifier>1</d:memberOfBoardIdentifier></xbrldi:typedMember></scenario></context><!--Virksomhedskapital aktuel primo--><context id="c87"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><instant>2020-07-31</instant></period><scenario><xbrldi:explicitMember dimension="g:ClassesOfEquityDimension">g:ContributedCapitalMember</xbrldi:explicitMember></scenario></context><!--Virksomhedskapital aktuel ultimo--><context id="c89"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><instant>2021-12-31</instant></period><scenario><xbrldi:explicitMember dimension="g:ClassesOfEquityDimension">g:ContributedCapitalMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel primo--><context id="c105"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><instant>2020-07-31</instant></period><scenario><xbrldi:explicitMember dimension="g:ClassesOfEquityDimension">g:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel i aaret--><context id="c106"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><startDate>2020-07-31</startDate><endDate>2021-12-31</endDate></period><scenario><xbrldi:explicitMember dimension="g:ClassesOfEquityDimension">g:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--Overfort res aktuel ultimo--><context id="c107"><entity><identifier scheme="http://www.dcca.dk/cvr">41590939</identifier></entity><period><instant>2021-12-31</instant></period><scenario><xbrldi:explicitMember dimension="g:ClassesOfEquityDimension">g:RetainedEarningsMember</xbrldi:explicitMember></scenario></context><!--DKK enere--><unit id="u3"><measure>iso4217:DKK</measure></unit></xbrl>
