<?xml version="1.0" encoding="UTF-8"?><xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns="http://www.w3.org/1999/xhtml" xmlns:basis="http://xbrl.dcca.dk/Regnskab%202.0%20Basis" xmlns:lnk="http://www.xbrl.org/2003/linkbase" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:dst="http://xbrl.dcca.dk/dst" xmlns:cmn="http://xbrl.dcca.dk/cmn" xmlns:gsd="http://xbrl.dcca.dk/gsd" xmlns:mrv="http://xbrl.dcca.dk/mrv" xmlns:xh11d="http://www.w3.org/1999/xhtml/datatypes/" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2010-04-20" xmlns:fsa="http://xbrl.dcca.dk/fsa" xmlns:arr="http://xbrl.dcca.dk/arr" xmlns:ix="http://www.xbrl.org/2008/inlineXBRL" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:ifrs="http://xbrl.iasb.org/taxonomy/2009-04-01/ifrs" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:sob="http://xbrl.dcca.dk/sob">
   <lnk:schemaRef xlink:href="http://archprod.service.eogs.dk/taxonomy/20161001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByNatureIncludingManagementsReviewStatisticsAndTax20161001.xsd" xlink:type="simple"/>
   <xbrli:context id="c0">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:startDate>2016-01-01</xbrli:startDate>
         <xbrli:endDate>2016-12-31</xbrli:endDate>
      </xbrli:period>
   </xbrli:context>
   <xbrli:context id="c1">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:startDate>2015-01-01</xbrli:startDate>
         <xbrli:endDate>2015-12-31</xbrli:endDate>
      </xbrli:period>
   </xbrli:context>
   <xbrli:context id="c2">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:startDate>2016-01-01</xbrli:startDate>
         <xbrli:endDate>2016-12-31</xbrli:endDate>
      </xbrli:period>
      <xbrli:scenario>
         <xbrldi:explicitMember dimension="fsa:ResultDistributionDimension">fsa:RetainedEarningsMember</xbrldi:explicitMember>
      </xbrli:scenario>
   </xbrli:context>
   <xbrli:context id="c3">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:startDate>2015-01-01</xbrli:startDate>
         <xbrli:endDate>2015-12-31</xbrli:endDate>
      </xbrli:period>
      <xbrli:scenario>
         <xbrldi:explicitMember dimension="fsa:ResultDistributionDimension">fsa:RetainedEarningsMember</xbrldi:explicitMember>
      </xbrli:scenario>
   </xbrli:context>
   <xbrli:context id="c5">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:instant>2015-12-31</xbrli:instant>
      </xbrli:period>
   </xbrli:context>
   <xbrli:context id="c4">
      <xbrli:entity>
         <xbrli:identifier scheme="http://www.dcca.dk/cvr">34689253</xbrli:identifier>
      </xbrli:entity>
      <xbrli:period>
         <xbrli:instant>2016-12-31</xbrli:instant>
      </xbrli:period>
   </xbrli:context>
   <xbrli:unit id="u0">
      <xbrli:measure>iso4217:DKK</xbrli:measure>
   </xbrli:unit>
   <gsd:InformationOnTypeOfSubmittedReport basis:version="3" contextRef="c0" xml:lang="da">Årsrapport</gsd:InformationOnTypeOfSubmittedReport>
   <gsd:DateOfGeneralMeeting contextRef="c0">2017-05-31</gsd:DateOfGeneralMeeting>
   <gsd:NameAndSurnameOfChairmanOfGeneralMeeting contextRef="c0" xml:lang="da">Søren Stenderup</gsd:NameAndSurnameOfChairmanOfGeneralMeeting>
   <gsd:NameOfReportingEntity contextRef="c0" xml:lang="da">BBR DANMARK ApS</gsd:NameOfReportingEntity>
   <gsd:AddressOfReportingEntityStreetName contextRef="c0" xml:lang="da">Kvæsthusgade</gsd:AddressOfReportingEntityStreetName>
   <gsd:AddressOfReportingEntityStreetBuildingIdentifier contextRef="c0" xml:lang="da">5, 4</gsd:AddressOfReportingEntityStreetBuildingIdentifier>
   <gsd:AddressOfReportingEntityPostCodeIdentifier contextRef="c0" xml:lang="da">1251</gsd:AddressOfReportingEntityPostCodeIdentifier>
   <gsd:AddressOfReportingEntityDistrictName contextRef="c0" xml:lang="da">København K</gsd:AddressOfReportingEntityDistrictName>
   <gsd:TelephoneNumberOfReportingEntity contextRef="c0" xml:lang="da">70205252</gsd:TelephoneNumberOfReportingEntity>
   <gsd:EmailOfReportingEntity contextRef="c0" xml:lang="da">ss@bbrdanmark.dk</gsd:EmailOfReportingEntity>
   <gsd:IdentificationNumberCvrOfReportingEntity contextRef="c0" xml:lang="da">34689253</gsd:IdentificationNumberCvrOfReportingEntity>
   <gsd:ReportingPeriodStartDate contextRef="c0">2016-01-01</gsd:ReportingPeriodStartDate>
   <gsd:ReportingPeriodEndDate contextRef="c0">2016-12-31</gsd:ReportingPeriodEndDate>
   <mrv:ManagementsReview contextRef="c0" xml:lang="da">&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
&lt;strong&gt;Hovedaktiviteter&lt;/strong&gt;
&lt;br/&gt;Hovedaktiviteten er forskning og udvikling af lægemidler
&lt;br/&gt;
&lt;strong&gt;Udviklingen i aktiviteter og økonomiske forhold&lt;/strong&gt;
&lt;br/&gt;Selskabets aktivitet har været begrænset da patentmæssig status for hovedaktiviteter afventes
&lt;br/&gt;
&lt;strong&gt;Begivenheder efter regnskabets afslutning&lt;/strong&gt;
&lt;br/&gt;Der er ikke indtrufet væsentlige begivenheder efter regnskabets afslutning.&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;strong&gt;Øvrige forhold&lt;/strong&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;Revision er fravalgt for den kommende regnskabsperiode.
&lt;br/&gt; &lt;/p&gt;</mrv:ManagementsReview>
   <fsa:InformationOnReportingClassOfEntity contextRef="c0" xml:lang="da">Årsrapporten er aflagt i overensstemmelse med årsregnskabslovens bestemmelser for Regnskabsklasse B.</fsa:InformationOnReportingClassOfEntity>
   <fsa:ClassOfReportingEntity contextRef="c0" xml:lang="da">Regnskabsklasse B</fsa:ClassOfReportingEntity>
   <fsa:DisclosureOfAccountingPolicies contextRef="c0" xml:lang="da">&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
&lt;br/&gt; &lt;/p&gt;</fsa:DisclosureOfAccountingPolicies>
   <fsa:GrossResult contextRef="c0" decimals="0" unitRef="u0">113</fsa:GrossResult>
   <fsa:GrossResult contextRef="c1" decimals="0" unitRef="u0">-47</fsa:GrossResult>
   <fsa:ProfitLossFromOrdinaryOperatingActivities contextRef="c0" decimals="0" unitRef="u0">113</fsa:ProfitLossFromOrdinaryOperatingActivities>
   <fsa:ProfitLossFromOrdinaryOperatingActivities contextRef="c1" decimals="0" unitRef="u0">-47</fsa:ProfitLossFromOrdinaryOperatingActivities>
   <fsa:ProfitLossFromOrdinaryActivitiesBeforeTax contextRef="c0" decimals="0" unitRef="u0">113</fsa:ProfitLossFromOrdinaryActivitiesBeforeTax>
   <fsa:ProfitLossFromOrdinaryActivitiesBeforeTax contextRef="c1" decimals="0" unitRef="u0">-47</fsa:ProfitLossFromOrdinaryActivitiesBeforeTax>
   <fsa:TaxExpense contextRef="c0" decimals="0" unitRef="u0">0</fsa:TaxExpense>
   <fsa:TaxExpense contextRef="c1" decimals="0" unitRef="u0">0</fsa:TaxExpense>
   <fsa:ProfitLoss contextRef="c0" decimals="0" unitRef="u0">113</fsa:ProfitLoss>
   <fsa:ProfitLoss contextRef="c1" decimals="0" unitRef="u0">-47</fsa:ProfitLoss>
   <fsa:ProfitLoss contextRef="c2" decimals="0" unitRef="u0">113</fsa:ProfitLoss>
   <fsa:ProfitLoss contextRef="c3" decimals="0" unitRef="u0">-47</fsa:ProfitLoss>
   <fsa:ProfitLoss contextRef="c0" decimals="0" unitRef="u0">113</fsa:ProfitLoss>
   <fsa:ProfitLoss contextRef="c1" decimals="0" unitRef="u0">-47</fsa:ProfitLoss>
   <fsa:OtherShorttermReceivables contextRef="c5" decimals="0" unitRef="u0">0</fsa:OtherShorttermReceivables>
   <fsa:ShorttermReceivables contextRef="c5" decimals="0" unitRef="u0">0</fsa:ShorttermReceivables>
   <fsa:OtherShorttermInvestments contextRef="c5" decimals="0" unitRef="u0">0</fsa:OtherShorttermInvestments>
   <fsa:ShorttermInvestments contextRef="c5" decimals="0" unitRef="u0">0</fsa:ShorttermInvestments>
   <fsa:CashAndCashEquivalents contextRef="c4" decimals="0" unitRef="u0">66</fsa:CashAndCashEquivalents>
   <fsa:CashAndCashEquivalents contextRef="c5" decimals="0" unitRef="u0">0</fsa:CashAndCashEquivalents>
   <fsa:CurrentAssets contextRef="c4" decimals="0" unitRef="u0">66</fsa:CurrentAssets>
   <fsa:CurrentAssets contextRef="c5" decimals="0" unitRef="u0">0</fsa:CurrentAssets>
   <fsa:Assets contextRef="c4" decimals="0" unitRef="u0">66</fsa:Assets>
   <fsa:Assets contextRef="c5" decimals="0" unitRef="u0">0</fsa:Assets>
   <fsa:ContributedCapital contextRef="c4" decimals="0" unitRef="u0">80000</fsa:ContributedCapital>
   <fsa:ContributedCapital contextRef="c5" decimals="0" unitRef="u0">80000</fsa:ContributedCapital>
   <fsa:OtherReserves contextRef="c4" decimals="0" unitRef="u0">-1033415</fsa:OtherReserves>
   <fsa:OtherReserves contextRef="c5" decimals="0" unitRef="u0">-1035255</fsa:OtherReserves>
   <fsa:RetainedEarnings contextRef="c4" decimals="0" unitRef="u0">113</fsa:RetainedEarnings>
   <fsa:RetainedEarnings contextRef="c5" decimals="0" unitRef="u0">-47</fsa:RetainedEarnings>
   <fsa:Equity contextRef="c4" decimals="0" unitRef="u0">-953302</fsa:Equity>
   <fsa:Equity contextRef="c5" decimals="0" unitRef="u0">-955302</fsa:Equity>
   <fsa:ShorttermTradePayables contextRef="c4" decimals="0" unitRef="u0">953236</fsa:ShorttermTradePayables>
   <fsa:ShorttermTradePayables contextRef="c5" decimals="0" unitRef="u0">953702</fsa:ShorttermTradePayables>
   <fsa:OtherShorttermPayables contextRef="c4" decimals="0" unitRef="u0">0</fsa:OtherShorttermPayables>
   <fsa:OtherShorttermPayables contextRef="c5" decimals="0" unitRef="u0">1600</fsa:OtherShorttermPayables>
   <fsa:ShorttermLiabilitiesOtherThanProvisions contextRef="c4" decimals="0" unitRef="u0">953236</fsa:ShorttermLiabilitiesOtherThanProvisions>
   <fsa:ShorttermLiabilitiesOtherThanProvisions contextRef="c5" decimals="0" unitRef="u0">955302</fsa:ShorttermLiabilitiesOtherThanProvisions>
   <fsa:LiabilitiesOtherThanProvisions contextRef="c4" decimals="0" unitRef="u0">953236</fsa:LiabilitiesOtherThanProvisions>
   <fsa:LiabilitiesOtherThanProvisions contextRef="c5" decimals="0" unitRef="u0">955302</fsa:LiabilitiesOtherThanProvisions>
   <fsa:LiabilitiesAndEquity contextRef="c4" decimals="0" unitRef="u0">66</fsa:LiabilitiesAndEquity>
   <fsa:LiabilitiesAndEquity contextRef="c5" decimals="0" unitRef="u0">0</fsa:LiabilitiesAndEquity>
   <fsa:DisclosureOfMainActivitiesAndAccountingAndFinancialMatters contextRef="c0" xml:lang="da">&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;strong&gt;
    &lt;span&gt;
      &lt;span&gt;2. Oplysning om anvendelse af undtagelsesmuligheder for mikrovirksomheder&lt;/span&gt;
    &lt;/span&gt;
  &lt;/strong&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;Mikrovirksomheden anvender undtagelsen om at give oplysning om anvendt regnskabspraksis&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;Mikrovirksomheden anvender undtagelsen om at give oplysning om gæld, der forfalder til&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;betaling mere end 5 år efter balancetidspunktet&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;Mikrovirksomheden anvender undtagelsen om at give oplysning om visse særlige poster&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;Mikrovirksomheden anvender undtagelsen om at give oplysning om det gennemsnitlige antal&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;heltidsbeskæftigede i regnskabsåret&lt;/span&gt;
&lt;/p&gt;</fsa:DisclosureOfMainActivitiesAndAccountingAndFinancialMatters>
   <fsa:DisclosureOfOwnership contextRef="c0" xml:lang="da">&lt;h3 xmlns="http://www.w3.org/1999/xhtml"&gt;Ejerforhold&lt;/h3&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;Selskabet har registreret følgende aktionærer med mere end 5% af aktiekapitalens stemmerettigheder eller pålydende værdi:&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt; &lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt; &lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;Anglo Nordic Investments Limited&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;36 Spital Square&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;E1 6DY London&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;United Kingdom&lt;/span&gt;
&lt;/p&gt;
&lt;p xmlns="http://www.w3.org/1999/xhtml"&gt;
  &lt;span&gt;100% af anpartskapitalen&lt;/span&gt;
&lt;/p&gt;
&lt;h3 xmlns="http://www.w3.org/1999/xhtml"&gt; &lt;/h3&gt;</fsa:DisclosureOfOwnership>
   <sob:TheReportingEntityAppliesTheExceptionConcerningOptingOutOfTheStatementByManagementEtc contextRef="c0" xml:lang="da">true</sob:TheReportingEntityAppliesTheExceptionConcerningOptingOutOfTheStatementByManagementEtc>
   <fsa:TheCompanyHasPresentedTheAnnualReportEtcWithReferenceToTheDanishFinancialStatementsAct78aConcerningTheExceptionForReportingClassCMediumsizeSubsidiariesWhichChoosesToPresentTheAnnualReportEtcAccordingToReportingClassB contextRef="c0" xml:lang="da">false</fsa:TheCompanyHasPresentedTheAnnualReportEtcWithReferenceToTheDanishFinancialStatementsAct78aConcerningTheExceptionForReportingClassCMediumsizeSubsidiariesWhichChoosesToPresentTheAnnualReportEtcAccordingToReportingClassB>
   <fsa:SelectedElementsFromReportingClassC contextRef="c0" xml:lang="da">false</fsa:SelectedElementsFromReportingClassC>
   <fsa:SelectedElementsFromReportingClassD contextRef="c0" xml:lang="da">false</fsa:SelectedElementsFromReportingClassD>
   <fsa:AccountingPoliciesAreUnchangedFromPreviousPeriod contextRef="c0" xml:lang="da">true</fsa:AccountingPoliciesAreUnchangedFromPreviousPeriod>
   <gsd:PrecedingReportingPeriodStartDate contextRef="c0">2015-01-01</gsd:PrecedingReportingPeriodStartDate>
   <gsd:PredingReportingPeriodEndDate contextRef="c0">2015-12-31</gsd:PredingReportingPeriodEndDate>
   <cmn:TypeOfAuditorAssistance contextRef="c0" xml:lang="da">Ingen bistand</cmn:TypeOfAuditorAssistance>
   <gsd:NameOfSubmittingEnterprise contextRef="c0" xml:lang="da">Søren Stenderup</gsd:NameOfSubmittingEnterprise>
   <gsd:AddressOfSubmittingEnterpriseStreetAndNumber contextRef="c0" xml:lang="da">Kvæsthusgade 5c, 4</gsd:AddressOfSubmittingEnterpriseStreetAndNumber>
   <gsd:AddressOfSubmittingEnterprisePostcodeAndTown contextRef="c0" xml:lang="da">1251 København K</gsd:AddressOfSubmittingEnterprisePostcodeAndTown>
</xbrli:xbrl>