<?xml version="1.0" encoding="UTF-8"?><xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:arr="http://xbrl.dcca.dk/arr" xmlns:mrv="http://xbrl.dcca.dk/mrv" xmlns:cmn="http://xbrl.dcca.dk/cmn" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:sob="http://xbrl.dcca.dk/sob" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:fsa="http://xbrl.dcca.dk/fsa" xmlns:gsd="http://xbrl.dcca.dk/gsd" xmlns:dst="http://xbrl.dcca.dk/dst" xml:lang="uk"><link:schemaRef xlink:type="simple" xlink:href="http://archprod.service.eogs.dk/taxonomy/20161001/entryDanishGAAPBalanceSheetAccountFormIncomeStatementByFunctionIncludingManagementsReviewStatisticsAndTax20161001.xsd"/><context id="D-2017"><entity><identifier 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id="D-2017-dim-ParentOfSmallestGrou"><entity><identifier scheme="http://www.dcca.dk/cvr">26505933</identifier></entity><period><startDate>2017-01-01</startDate><endDate>2017-12-31</endDate></period><scenario><xbrldi:explicitMember dimension="fsa:TypeOfRelatedEntityDimension">fsa:ParentOfSmallestGroupInWhichReportingEntityIsSubsidiaryMember</xbrldi:explicitMember></scenario></context><context id="D-2017-dim-Revisionsvirksomhed0"><entity><identifier scheme="http://www.dcca.dk/cvr">26505933</identifier></entity><period><startDate>2017-01-01</startDate><endDate>2017-12-31</endDate></period><scenario><xbrldi:typedMember dimension="cmn:IdentificationOfAuditorDimension"><auditorIdentifier xmlns="http://xbrl.dcca.dk/cmn">Revisionsvirksomhed 01</auditorIdentifier></xbrldi:typedMember></scenario></context><context id="D-2017-dim-Revisionsvirksomhed0.1"><entity><identifier scheme="http://www.dcca.dk/cvr">26505933</identifier></entity><period><startDate>2017-01-01</startDate><endDate>2017-12-31</endDate></period><scenario><xbrldi:typedMember dimension="cmn:IdentificationOfAuditorDimension"><auditorIdentifier xmlns="http://xbrl.dcca.dk/cmn">Revisionsvirksomhed 01 - Revisor 01</auditorIdentifier></xbrldi:typedMember></scenario></context><unit id="u-DKK"><measure>iso4217:DKK</measure></unit><mrv:DescriptionOfPrimaryActivitiesOfEntity contextRef="D-2017">The activity of the Company included the development of the medicinal product candidate Balaglitazone. The Company has been without activity during the year.</mrv:DescriptionOfPrimaryActivitiesOfEntity><mrv:DescriptionOfDevelopmentInActivitiesAndFinancialAffairs contextRef="D-2017">The Company's income statement for 2017 shows a profit of DKK 5,228 while the balance sheet shows negative equity of DKK 33,813,225 at 31.12.2017.</mrv:DescriptionOfDevelopmentInActivitiesAndFinancialAffairs><mrv:DescriptionOfSignificantEventsOccurringAfterEndOfReportingPeriod contextRef="D-2017">No events have occurred after the balance sheet date to this date, which would influence the evaluation of this annual report.</mrv:DescriptionOfSignificantEventsOccurringAfterEndOfReportingPeriod><cmn:NameAndSurnameOfMemberOfExecutiveBoard contextRef="D-2017-dim-Direktionsmedlem01">Thomas Nielsen</cmn:NameAndSurnameOfMemberOfExecutiveBoard><sob:IdentificationOfApprovedAnnualReport contextRef="D-2017">The Executive Board has today considered and approved the annual report of Rheoscience ApS for the financial year 01.01.2017 - 31.12.2017.</sob:IdentificationOfApprovedAnnualReport><sob:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement contextRef="D-2017">The annual report is presented in accordance with the Danish Financial Statements Act.</sob:ConfirmationThatAnnualReportIsPresentedInAccordanceWithRequirementsProvidedForByLegislationAnyStandardsAndRequirementsProvidedByArticlesOfAssociationOrByAgreement><sob:RecommendationForApprovalOfAnnualReportByGeneralMeeting contextRef="D-2017">I recommend the annual report for adoption at the Annual General Meeting.</sob:RecommendationForApprovalOfAnnualReportByGeneralMeeting><sob:ManagementsStatementAboutManagementsReview contextRef="D-2017">I believe that the management commentary contains a fair review of the affairs and conditions referred to therein.</sob:ManagementsStatementAboutManagementsReview><fsa:ShorttermReceivables unitRef="u-DKK" decimals="0" contextRef="I-2017-E">11654625</fsa:ShorttermReceivables><fsa:ShorttermReceivables unitRef="u-DKK" decimals="0" contextRef="I-2016-E">11661000</fsa:ShorttermReceivables><fsa:CashAndCashEquivalents unitRef="u-DKK" decimals="0" contextRef="I-2017-E">24439</fsa:CashAndCashEquivalents><fsa:CashAndCashEquivalents unitRef="u-DKK" decimals="0" contextRef="I-2016-E">12094</fsa:CashAndCashEquivalents><fsa:Assets unitRef="u-DKK" decimals="0" contextRef="I-2017-E">11679064</fsa:Assets><fsa:Assets unitRef="u-DKK" decimals="0" contextRef="I-2016-E">11673094</fsa:Assets><fsa:CurrentAssets unitRef="u-DKK" decimals="0" contextRef="I-2017-E">11679064</fsa:CurrentAssets><fsa:CurrentAssets unitRef="u-DKK" decimals="0" contextRef="I-2016-E">11673094</fsa:CurrentAssets><fsa:CurrentDeferredTaxAssets unitRef="u-DKK" decimals="0" contextRef="I-2017-E">11654209</fsa:CurrentDeferredTaxAssets><fsa:CurrentDeferredTaxAssets unitRef="u-DKK" decimals="0" contextRef="I-2016-E">11654209</fsa:CurrentDeferredTaxAssets><fsa:OtherShorttermReceivables unitRef="u-DKK" decimals="0" contextRef="I-2017-E">416</fsa:OtherShorttermReceivables><fsa:OtherShorttermReceivables unitRef="u-DKK" decimals="0" contextRef="I-2016-E">6791</fsa:OtherShorttermReceivables><fsa:LiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2017-E">45492289</fsa:LiabilitiesOtherThanProvisions><fsa:LiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2016-E">45491547</fsa:LiabilitiesOtherThanProvisions><fsa:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments unitRef="u-DKK" decimals="0" contextRef="I-2017-E">39201643</fsa:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments><fsa:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments unitRef="u-DKK" decimals="0" contextRef="I-2016-E">39201644</fsa:ConvertibleProfitYieldingOrDividendYieldingLongtermDebtInstruments><fsa:ShorttermPayablesToGroupEnterprises unitRef="u-DKK" decimals="0" contextRef="I-2017-E">6280346</fsa:ShorttermPayablesToGroupEnterprises><fsa:ShorttermPayablesToGroupEnterprises unitRef="u-DKK" decimals="0" contextRef="I-2016-E">6279903</fsa:ShorttermPayablesToGroupEnterprises><fsa:OtherShorttermPayables unitRef="u-DKK" decimals="0" contextRef="I-2017-E">10300</fsa:OtherShorttermPayables><fsa:OtherShorttermPayables unitRef="u-DKK" decimals="0" contextRef="I-2016-E">10000</fsa:OtherShorttermPayables><fsa:OtherOperatingIncome unitRef="u-DKK" decimals="0" contextRef="D-2017">16903</fsa:OtherOperatingIncome><fsa:AdministrativeExpenses unitRef="u-DKK" decimals="0" contextRef="D-2017">11100</fsa:AdministrativeExpenses><fsa:AdministrativeExpenses unitRef="u-DKK" decimals="0" contextRef="D-2016">10000</fsa:AdministrativeExpenses><fsa:RestOfOtherFinanceExpenses unitRef="u-DKK" decimals="0" contextRef="D-2017">131</fsa:RestOfOtherFinanceExpenses><fsa:RestOfOtherFinanceExpenses unitRef="u-DKK" decimals="0" contextRef="D-2016">200547</fsa:RestOfOtherFinanceExpenses><fsa:GrossProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2017">16903</fsa:GrossProfitLoss><fsa:ProfitLossFromOrdinaryOperatingActivities unitRef="u-DKK" decimals="0" contextRef="D-2017">5803</fsa:ProfitLossFromOrdinaryOperatingActivities><fsa:ProfitLossFromOrdinaryOperatingActivities unitRef="u-DKK" decimals="0" contextRef="D-2016">-10000</fsa:ProfitLossFromOrdinaryOperatingActivities><fsa:ProfitLossFromOrdinaryActivitiesBeforeTax unitRef="u-DKK" decimals="0" contextRef="D-2017">5672</fsa:ProfitLossFromOrdinaryActivitiesBeforeTax><fsa:ProfitLossFromOrdinaryActivitiesBeforeTax unitRef="u-DKK" decimals="0" contextRef="D-2016">-210547</fsa:ProfitLossFromOrdinaryActivitiesBeforeTax><fsa:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies contextRef="D-2017">Assets are recognised in the balance sheet when it is probable as a result of a prior event that future economic benefits will flow to the Entity, and the value of the asset can be measured reliably.
Liabilities are recognised in the balance sheet when the Entity has a legal or constructive obligation as a result of a prior event, and it is probable that future economic benefits will flow out of the Entity, and the value of the liability can be measured reliably.
On initial recognition, assets and liabilities are measured at cost. Measurement subsequent to initial recognition is effected as described below for each financial statement item.
Anticipated risks and losses that arise before the time of presentation of the annual report and that confirm or invalidate affairs and conditions existing at the balance sheet date are considered at recognition and measurement.
Income is recognised in the income statement when earned, whereas costs are recognised by the amounts attributable to this financial year.</fsa:DescriptionOfGeneralMattersRelatedToRecognitionMeasurementAndChangesInAccountingPolicies><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables contextRef="D-2017">Receivables are measured at amortised cost, usually equalling nominal value, less write-downs for bad and doubtful debts.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfReceivables><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxPayablesAndDeferredTax contextRef="D-2017">Deferred tax is recognised on all temporary differences between the carrying amount and the tax-based value of assets and liabilities, for which the tax-based value is calculated based on the planned use of each asset.
Deferred tax assets, including the tax base of tax loss carryforwards, are recognised in the balance sheet at their estimated realisable value, either as a set-off against deferred tax liabilities or as net tax assets.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxPayablesAndDeferredTax><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents contextRef="D-2017">Cash comprises cash in hand and bank deposits.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfCashAndCashEquivalents><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions contextRef="D-2017">Other financial liabilities are measured at amortised cost, which usually corresponds to nominal value.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfLiabilitiesOtherThanProvisions><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfAdministrativeExpenses contextRef="D-2017">Administrative costs comprise expenses incurred for the Entity’s administrative functions, including wages and salaries for administrative staff and Management, stationery and office supplies as well as amortisation, depreciation and impairment losses relating to intangible assets and property, plant and equipment used for administration of the Entity.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfAdministrativeExpenses><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfFinanceIncomeAndExpenses contextRef="D-2017">Other financial expenses comprise interest expenses, including interest expenses on payables to group enterprises, net capital losses on securities, payables and transactions in foreign currencies, amortisation of financial liabilities as well as tax surcharge under the Danish Tax Prepayment Scheme etc.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfFinanceIncomeAndExpenses><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxExpenses contextRef="D-2017">Tax for the year, which consists of current tax for the year and changes in deferred tax, is recognised in the income statement by the portion attributable to the profit for the year and recognised directly in equity by the portion attributable to entries directly in equity. The Entity is jointly taxed with the Parent and all of its Danish subsidiaries. The current Danish income tax is allocated among the jointly taxed entities proportionally to their taxable income (full allocation with a refund concerning tax losses). </fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfTaxExpenses><fsa:CurrentTaxExpense unitRef="u-DKK" decimals="0" contextRef="D-2017">444</fsa:CurrentTaxExpense><fsa:CurrentTaxExpense unitRef="u-DKK" decimals="0" contextRef="D-2016">-46321</fsa:CurrentTaxExpense><fsa:OtherReceivables unitRef="u-DKK" decimals="0" contextRef="I-2017-E">416</fsa:OtherReceivables><fsa:OtherReceivables unitRef="u-DKK" decimals="0" contextRef="I-2016-E">6791</fsa:OtherReceivables><gsd:IdentificationNumberCvrOfReportingEntity contextRef="D-2017">26505933</gsd:IdentificationNumberCvrOfReportingEntity><gsd:NameOfReportingEntity contextRef="D-2017">Rheoscience ApS</gsd:NameOfReportingEntity><gsd:DateOfFoundationOfReportingEntity contextRef="D-2017">2002-03-11</gsd:DateOfFoundationOfReportingEntity><gsd:RegisteredOfficeOfReportingEntity contextRef="D-2017">Herlev</gsd:RegisteredOfficeOfReportingEntity><gsd:DateOfGeneralMeeting contextRef="D-2017">2018-05-17</gsd:DateOfGeneralMeeting><gsd:NameAndSurnameOfChairmanOfGeneralMeeting contextRef="D-2017">Thomas Nielsen</gsd:NameAndSurnameOfChairmanOfGeneralMeeting><sob:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults contextRef="D-2017">In my opinion, the financial statements give a true and fair view of the Entity’s financial position at 31.12.2017 and of the results of its operations for the financial year 01.01.2017 - 31.12.2017.</sob:ConfirmationThatFinancialStatementGivesTrueAndFairViewOfAssetsLiabilitiesEquityFinancialPositionAndResults><sob:DateOfApprovalOfAnnualReport contextRef="D-2017">2018-05-17</sob:DateOfApprovalOfAnnualReport><sob:PlaceOfSignatureOfStatement contextRef="D-2017">Herlev</sob:PlaceOfSignatureOfStatement><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfIncomeStatementItems contextRef="D-2017">Gross profit or loss comprises revenue and other operating income.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfIncomeStatementItems><fsa:DisclosureOfShorttermLiabilities contextRef="D-2017"/><fsa:DisclosureOfContingentLiabilities contextRef="D-2017">The Entity participates in a Danish joint taxation arrangement in which Nordic Bioscience Holding A/S serves as the administration company. According to the joint taxation provisions of the Danish Corporation Tax Act, the Entity is therefore liable for income taxes etc for the jointly taxed entities, and for obligations, if any, relating to the withholding of tax on interest, royalties and dividend for the jointly taxed entities. The jointly taxed entities' total known net liability under the joint taxation arrangement is disclosed in the administration company's financial statements.</fsa:DisclosureOfContingentLiabilities><gsd:IdentificationNumberCvrOfSubmittingEnterprise contextRef="D-2017">33963556</gsd:IdentificationNumberCvrOfSubmittingEnterprise><gsd:NameOfSubmittingEnterprise contextRef="D-2017">Deloitte Statsautoriseret Revisionspartnerselskab</gsd:NameOfSubmittingEnterprise><gsd:AddressOfSubmittingEnterpriseStreetAndNumber contextRef="D-2017">Weidekampsgade P.O. Box 1600</gsd:AddressOfSubmittingEnterpriseStreetAndNumber><gsd:AddressOfSubmittingEnterprisePostcodeAndTown contextRef="D-2017">0900 Copenhagen C</gsd:AddressOfSubmittingEnterprisePostcodeAndTown><fsa:LiabilitiesAndEquity unitRef="u-DKK" decimals="0" contextRef="I-2017-E">11679064</fsa:LiabilitiesAndEquity><fsa:LiabilitiesAndEquity unitRef="u-DKK" decimals="0" contextRef="I-2016-E">11673094</fsa:LiabilitiesAndEquity><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2017-E">-33813225</fsa:Equity><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2016-E">-33818453</fsa:Equity><fsa:ContributedCapital unitRef="u-DKK" decimals="0" contextRef="I-2017-E">32459518</fsa:ContributedCapital><fsa:ContributedCapital unitRef="u-DKK" decimals="0" contextRef="I-2016-E">32459518</fsa:ContributedCapital><fsa:RetainedEarnings unitRef="u-DKK" decimals="0" contextRef="I-2017-E">-66272743</fsa:RetainedEarnings><fsa:RetainedEarnings unitRef="u-DKK" decimals="0" contextRef="I-2016-E">-66277971</fsa:RetainedEarnings><fsa:LongtermLiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2017-E">39201643</fsa:LongtermLiabilitiesOtherThanProvisions><fsa:LongtermLiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2016-E">39201644</fsa:LongtermLiabilitiesOtherThanProvisions><fsa:ShorttermLiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2017-E">6290646</fsa:ShorttermLiabilitiesOtherThanProvisions><fsa:ShorttermLiabilitiesOtherThanProvisions unitRef="u-DKK" decimals="0" contextRef="I-2016-E">6289903</fsa:ShorttermLiabilitiesOtherThanProvisions><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2017">5228</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2016">-164226</fsa:ProfitLoss><fsa:TaxExpenseOnOrdinaryActivities unitRef="u-DKK" decimals="0" contextRef="D-2017">444</fsa:TaxExpenseOnOrdinaryActivities><fsa:TaxExpenseOnOrdinaryActivities unitRef="u-DKK" decimals="0" contextRef="D-2016">-46321</fsa:TaxExpenseOnOrdinaryActivities><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2017-dim-RetainedEarningsMemb">5228</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2016-dim-RetainedEarningsMemb">-164226</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2017">5228</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2016">-164226</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2017-dim-RetainedEarningsMemb.1">5228</fsa:ProfitLoss><fsa:ProfitLoss unitRef="u-DKK" decimals="0" contextRef="D-2016-dim-RetainedEarningsMemb.1">-164226</fsa:ProfitLoss><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2017-E-dim-ContributedCapitalMe">32459518</fsa:Equity><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2016-E-dim-ContributedCapitalMe">32459518</fsa:Equity><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2017-E-dim-RetainedEarningsMemb">-66272743</fsa:Equity><fsa:Equity unitRef="u-DKK" decimals="0" contextRef="I-2016-E-dim-RetainedEarningsMemb">-66277971</fsa:Equity><fsa:RelatedEntityNameConsolidatedFinancialStatements contextRef="D-2017-dim-ParentOfSmallestGrou">
Nordic Bioscience Holding A/S, Herlev</fsa:RelatedEntityNameConsolidatedFinancialStatements><arr:StatementOfExecutiveAndSupervisoryBoardsResponsibilityForFinancialStatements contextRef="D-2017">Management is responsible for the preparation of financial statements that give a true and fair view in accordance with the Danish Financial Statements Act, and for such internal control as Management determines is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.
In preparing the financial statements, Management is responsible for assessing the Entity’s ability to continue as a going concern, for disclosing, as applicable, matters related to going concern, and for using the going concern basis of accounting in preparing the financial statements unless Management either intends to liquidate the Entity or to cease operations, or has no realistic alternative but to do so.</arr:StatementOfExecutiveAndSupervisoryBoardsResponsibilityForFinancialStatements><arr:StatementOfAuditorsResponsibilityForAuditAndAuditPerformed contextRef="D-2017">Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.
As part of an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark, we exercise professional judgement and maintain professional scepticism throughout the audit. We also:
•	Identify and assess the risks of material misstatement of the financial statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control.
•	Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Entity’s internal control.
•	Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by Management.
•	Conclude on the appropriateness of Management’s use of the going concern basis of accounting in preparing the financial statements, and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Entity’s ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor’s report to the related disclosures in the financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor’s report. However, future events or conditions may cause the Entity to cease to continue as a going concern.
•	Evaluate the overall presentation, structure and content of the financial statements, including the disclosures in the notes, and whether the financial statements represent the underlying transactions and events in a manner that gives a true and fair view.
We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. </arr:StatementOfAuditorsResponsibilityForAuditAndAuditPerformed><arr:DescriptionOfQualificationsOfAuditedFinancialStatements contextRef="D-2017">We conducted our audit in accordance with International Standards on Auditing (ISAs) and additional requirements applicable in Denmark. Our responsibilities under those standards and requirements are further described in the Auditor’s responsibilities for the audit of the financial statements section of this auditor’s report. We are independent of the Entity in accordance with the International Ethics Standards Board of Accountants' Code of Ethics for Professional Accountants (IESBA Code) and the additional requirements applicable in Denmark, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.</arr:DescriptionOfQualificationsOfAuditedFinancialStatements><arr:OpinionOnAuditedFinancialStatements contextRef="D-2017">We have audited the financial statements of Rheoscience ApS for the financial year 01.01.2017 - 31.12.2017, which comprise the income statement, balance sheet, statement of changes in equity and notes, including a summary of significant accounting policies. The financial statements are prepared in accordance with the Danish Financial Statements Act.
In our opinion, the financial statements give a true and fair view of the Entity’s financial position at 31.12.2017 and of the results of its operations for the financial year 01.01.2017 - 31.12.2017 in accordance with the Danish Financial Statements Act.</arr:OpinionOnAuditedFinancialStatements><arr:StatementOnManagementsReviewAuditorsReportOnAuditedFinancialStatements contextRef="D-2017">Management is responsible for the management commentary.
Our opinion on the financial statements does not cover the management commentary, and we do not express any form of assurance conclusion thereon.
In connection with our audit of the financial statements, our responsibility is to read the management commentary and, in doing so, consider whether the management commentary is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated.
Moreover, it is our responsibility to consider whether the management commentary provides the information required under the Danish Financial Statements Act.Based on the work we have performed, we conclude that the management commentary is in accordance with the financial statements and has been prepared in accordance with the requirements of the Danish Financial Statements Act. We did not identify any material misstatement of the management commentary. </arr:StatementOnManagementsReviewAuditorsReportOnAuditedFinancialStatements><gsd:InformationOnTypeOfSubmittedReport contextRef="D-2017">Årsrapport</gsd:InformationOnTypeOfSubmittedReport><fsa:ClassOfReportingEntity contextRef="D-2017">Regnskabsklasse B</fsa:ClassOfReportingEntity><arr:AddresseeOfAuditorsReportOnAuditedFinancialStatements contextRef="D-2017">To the shareholders of Rheoscience ApS</arr:AddresseeOfAuditorsReportOnAuditedFinancialStatements><fsa:DisclosureOfUncertaintiesRelatingToGoingConcern contextRef="D-2017">The Company has lost its share capital. Meanwhile, the Company's current liabilities are much higher than the current assets. The Company's ability to continue as a going concern depends on the Parent, Nordic Bioscience A/S. The Parent has promised to make the necessary credit facilities available to the Company in 2018. Accordingly, the financial statements have been presented on the assumption that the Company is a going concern.</fsa:DisclosureOfUncertaintiesRelatingToGoingConcern><arr:SignatureOfAuditorsPlace contextRef="D-2017">Copenhagen</arr:SignatureOfAuditorsPlace><arr:SignatureOfAuditorsDate contextRef="D-2017">2018-05-17</arr:SignatureOfAuditorsDate><gsd:AddressOfReportingEntityStreetName contextRef="D-2017">Herlev Hovedgade</gsd:AddressOfReportingEntityStreetName><gsd:AddressOfReportingEntityStreetBuildingIdentifier contextRef="D-2017">205-207</gsd:AddressOfReportingEntityStreetBuildingIdentifier><gsd:AddressOfReportingEntityPostCodeIdentifier contextRef="D-2017">2730</gsd:AddressOfReportingEntityPostCodeIdentifier><gsd:AddressOfReportingEntityDistrictName contextRef="D-2017">Herlev</gsd:AddressOfReportingEntityDistrictName><gsd:AddressOfAuditorStreetName contextRef="D-2017-dim-Revisionsvirksomhed0">WeidekampsgadeP.O. Box 1600</gsd:AddressOfAuditorStreetName><gsd:AddressOfAuditorStreetBuildingIdentifier contextRef="D-2017-dim-Revisionsvirksomhed0">6</gsd:AddressOfAuditorStreetBuildingIdentifier><gsd:AddressOfAuditorPostCodeIdentifier contextRef="D-2017-dim-Revisionsvirksomhed0">0900</gsd:AddressOfAuditorPostCodeIdentifier><gsd:AddressOfAuditorDistrictName contextRef="D-2017-dim-Revisionsvirksomhed0">Copenhagen C</gsd:AddressOfAuditorDistrictName><fsa:DescriptionOfMethodsOfTranslationOfForeignCurrencies contextRef="D-2017"/><fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfOtherOperatingIncome contextRef="D-2017">Other operating income comprises income of a secondary nature as viewed in relation to the Entity’s primary activities.</fsa:DescriptionOfMethodsOfRecognitionAndMeasurementBasisOfOtherOperatingIncome><cmn:TypeOfAuditorAssistance contextRef="D-2017">Revisionspåtegning</cmn:TypeOfAuditorAssistance><fsa:ProfitLossAfterAttributableToMinorityInterest unitRef="u-DKK" decimals="0" contextRef="D-2017">5228</fsa:ProfitLossAfterAttributableToMinorityInterest><fsa:ProfitLossAfterAttributableToMinorityInterest unitRef="u-DKK" decimals="0" contextRef="D-2016">-164226</fsa:ProfitLossAfterAttributableToMinorityInterest><fsa:DisclosureOfAccountingPolicies contextRef="D-2017">The accounting policies applied to these financial statements are consistent with those applied last year. </fsa:DisclosureOfAccountingPolicies><arr:InformationOnSignatureInternalAudit contextRef="D-2017"/><cmn:DescriptionOfAuditor contextRef="D-2017-dim-Revisionsvirksomhed0.1">State-Authorised Public Accountant</cmn:DescriptionOfAuditor><cmn:NameAndSurnameOfAuditor contextRef="D-2017-dim-Revisionsvirksomhed0.1">Jan Larsen</cmn:NameAndSurnameOfAuditor><gsd:TelephoneNumberOfAuditor contextRef="D-2017-dim-Revisionsvirksomhed0">+4536102030</gsd:TelephoneNumberOfAuditor><arr:MaterialUncertaintyConcerningGoingConcernAudit contextRef="D-2017">Without affecting our opinion, we draw attention to the information provided in note 1, at which management accounts for the uncertainty surronding the Company’s ability to continue as a going concern. The Company has received commitment from the Parent, that the necessary credit facilities will be maintained for the calendar year 2018. The financial statements have been presented as a going concern. 
</arr:MaterialUncertaintyConcerningGoingConcernAudit><gsd:ReportingPeriodStartDate contextRef="D-2017">2017-01-01</gsd:ReportingPeriodStartDate><gsd:ReportingPeriodEndDate contextRef="D-2017">2017-12-31</gsd:ReportingPeriodEndDate><gsd:PredingReportingPeriodEndDate contextRef="D-2017">2016-12-31</gsd:PredingReportingPeriodEndDate><gsd:PrecedingReportingPeriodStartDate contextRef="D-2017">2016-01-01</gsd:PrecedingReportingPeriodStartDate><cmn:IdentificationNumberOfAuditor contextRef="D-2017-dim-Revisionsvirksomhed0.1">mne16541</cmn:IdentificationNumberOfAuditor><cmn:IdentificationNumberCvrOfAuditFirm contextRef="D-2017-dim-Revisionsvirksomhed0.1">33963556</cmn:IdentificationNumberCvrOfAuditFirm><cmn:NameOfAuditFirm contextRef="D-2017-dim-Revisionsvirksomhed0.1">Deloitte Statsautoriseret Revisionspartnerselskab</cmn:NameOfAuditFirm></xbrl>